A Study On Lung Cancer - 1721 Words

Introduction: Lung cancers are well known to display inter and intra-tumoral heterogeneity with profound implications for exact histological classification by pathologists1–3. The New International (IASLC/ATS/ERS )4,5 and the 2015 World Health Organization (WHO) classification6 has defined the non-invasive (adenocarcinoma in situ), minimally invasive adenocarcinoma and invasive lepidic adenocarcinoma ; has replaced the mixed subtype category in the WHO 2004 classification7 with the predominant subtype ; included the micropapillary subtype8,9 and replaced the term â€Å"mucinous bronchioloalveolar carcinoma(BAC)† with invasive mucinous adenocarcinoma. This study aimed to do a comprehensive histological subtyping and detailed study of†¦show more content†¦Amongst 237 cases, a significant proportion 195(82.2%) were at stage IV at diagnosis, fewer 31(13.5%) at stage III and 11(4.7%) at Stage II and none at Stage I. Histologic findings: The 2015 WHO classification of lung tumours (add ref) was used to categorise biopsies by the predominant histological subtype. Of 274 cases, 167 (61%) were acinar predominant adenocarcinomas, 63(23%) solid adenocarcinomas, 19 (7%) invasive mucinous adenocarcinomas, 11(4%)lepidic predominant, papillary 9 (3.30%), two cases each of colloid (0.7%) and non- small cell carcinoma, not otherwise specified (NSCC-NOS) (0.7%) and one micro-papillary predominant subtype (0.3%) (Figure 1; Figures 2A-2D; Figures 3A-3D). The polygonal cell type was the most frequent comprising 160(58.40%) followed by columnar 69(25.2%), cuboidal 38(13.9%), signet ring 4(1.4%), hobnail 2 (0.7%) and clear cell 1(0.4%) cell types. A significant percentage of tumours were associated with mucin production, desmoplasia, stromal elastosis, lympho-vascular invasion and necrosis (Table 1). Lymphovascular invasion was most commonly seen amongst stage III/ stage IV disease in 187/226 (82.7%). The majority of tumours, 213/263 (81%) were TTF-1 positive. Almost all cases, 134/135 (99.3%) demonstrated positivity for CK7 and Ber-EP4 63/65 (97%). Correlation of histologic subtypes with clinical features: The papillary subtype in 7/7 (100%) followed by the lepidic predominant in 4/5(80%), acinar in 75/102Show MoreRelatedA Study On Lung Cancer1329 Words   |  6 Pages4963644 Case Study: George Introduction: George is an 89 year old man which recently has been diagnosed with Metastatic Lung Cancer. Lung cancer itself accounts for killing an estimated 1.5 million people annually worldwide (Keshamouni, et.al, 2009). Lung cancer is divided into two major types: Non-small-cell cancer which includes these types of cancers; adenocarcinoma, squamous cell and large-cell, these all account to 80% of cases. 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This abnormal growth can occur in either one of both of the lungs. The abnormal cells cause the development of unhealthy lung tissue, which causes the lungs to not function properly. The main function of the lungs is to provide oxygen to the body via the blood. Some of the symptoms of lung cancer are a persistent cough, shortness of breath, recurrent pneumonia, change in sputum, and coughing up blood (What is Lung,). Lung cancer isRead MoreThe Ten Attributes Of The University Of Queensland1174 Words   |  5 Pagesseventeen attributes of the University of Queensland that was demonstrated during the management of the particular case study. Although all seventeen attributes should correlate and in fact are interrelated, this assignment will analyse and focus on one attribute: â€Å"The ability to interact effectively with others in order to work towards a common outcome†. 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The Molecular Basis of Inheritance Free Essays

THE MOLECULAR BASIS OF INHERITANCE I. History A. Discovery of â€Å"transformation† – a change in genotype and phenotype due to the uptake of external DNA by a cell 1. We will write a custom essay sample on The Molecular Basis of Inheritance or any similar topic only for you Order Now Griffith 1920s did experiments with Streptococcus pneumoniae (p294 fig16. 2) a. took two strains of S. pneumoniae, one virulent, one not b. heat killed virulent strain, then mixed them with the living nonvirulent strain c. living nonvirulent strain became virulent d. nonvirulent strain took on virulent strain’s DNA ? became virulent e. see p294 fig16. 2 S strain = virulent, R = nonvirulent f. ventually Griffith’s work lead way to more studies on DNA being the carrier of genetic info. B. Proof that viral DNA and not viral protein contains genetic information to make more viral particles 1. Hershey and Chase 1950s p295 fig16. 4 a. knew that viruses could infect bacteria and make more viruses using the host cell’s replicating ‘machinery’ b. background: sulfur gets incorporated into virus’ protein/phosphorus into virus’ DNA c. took T4 (bacteriophage) and plated with a lawn of E. coli and radioactively labeled sulfur, result = T4 with radio active labeled protein (DNA not labeled) d. took T4 and plated with E. oli and radioactively labeled phosphorus = T4 with radioactively labeled DNA (protein not labeled) e. background: when virus + bacteria is spun down, viral particles in supernatant and bacteria in pellet f. took T4 (S-labeled) infected new E. coli lawn, spun down, found S-radioactive labels in supernatant g. took T4 (P-labeled) infected new E. coli lawn, spun down, found P-radioactive labels in pellet h. result = it’s the DNA that’s injected into the host to make more virus (even plated these spun down pellet bacteria, and they lysed and released new virus C. Discovery of the structure of DNA 1. Watson and Crick a. used an x-ray crystallography picture (p297) by Franklin to determine DNA as a double-helical structure b. review p298 – A pairs with T and G with C/ A and G are purines and C and T are pyrimidines/double hydrogen bonds between A and T, and triple between G and C II. DNA Replication A. 3 models of DNA replication p300 fig 16. 10 1. Conservative model – the parental helix splits, copies, then goes back together again to remain intact while a second entirely new copy is made 2. Semiconservative model – the parental helix splits, copies and remains a part of the two new helixes 3. Dispersive model – the parental helix splits unevenly, copies and remains a part of the two new helixes but in pieces B. Experimental proof p300 fig16. 11 1. added radioactively labeled heavy nitrogen to replicating bacteria, then placed this culture into radioactively labeled light nitrogen (used to distinguish strands) 2. allowed bacteria to replicate again, results gave hybrid DNA strands (ruled out conservative model) (note: both hybrids half and half and totally mixed look the same, so semiconservative and dispersive models both upheld this time- see below) 3. llowed bacteria to replicate again, results gave hybrid strands and only light double strands (ruled out dispersive model since all should be mixed if this was right) C. Origins of replication p301 fig16. 12 1. origin of replication – site where DNA replication begins a. proteins recognize a specific sequence on the template DNA, open the dsDNA to make a bubble, and begin replication b. replication fork †“ location on DNA strand where new DNA strand is growing 1. prokaryotes plasmid (single circular dsDNA helix) have one origin of replication and replication occurs in both directions 2. ukaryotes have linear dsDNA have many origins and replication occurs in both directions D. Elongation of new DNA 1. DNA polymerase – enzyme that synthesizes the new DNA strand by adding nucleotides to the growing strand 2. DNA polymerase receives energy to do this by nucleotides being nucleoside triphosphate (CTP, GTP, ATP, TTP) since they lose Pii = exergonic reaction to supply energy E. DNA is antiparallel p302 1. carbon numbering – carbon attached to base is 1’, count clockwise, carbon attached to phosphate group is 3’, carbon attached to other phosphate group is 5’ 2. be able to find 5’ vs 3’ end . (p302 fig 16. 14) replication occurs 5’ ? 3’, so strand being made in this direction is called the leading strand and replication occurs toward the replication fork 4. lagging strand is replication that occurs 5’ ? 3’ but replication moves away from the replication fork a. lagging strand produces Okazaki fragments which must be connected with DNA ligase p303 fig 16. 15 F. Priming DNA synthesis (getting replication started) p303 fig16. 15 1. primer – existing RNA polynucleotide on the template DNA strand since DNA polymerase cannot just start adding new nucleotides on its own a. rimer is laid down by enzyme primase b. only one primer required for leading strand to begin synthesizing/new RNA primer required for each lagging strand beginning c. DNA polymerase eventually replaces RNA nucleotides with DNA ones and occurs before ligase connects any lagging DNA strands G. Other assisting proteins 1. helicase – enzyme that unwinds dsDNA at the replication form 2. single-strand binding proteins – hold apart template DNA while replication occurs **FINAL GOOD SUMMARY P304 fig 16. 16 III. DNA Proofreading and Repair A. Mismatch repair 1. as DNA polymerase lays down nucleotides, if it notices a mismatched one to template, will remove and replace with correct one 2. Excision repair p305 fig16. 17: consists of nuclease – enzyme that can cut out damaged segments of a DNA strand, then new nucleotides are filled in based on what the other DNA strand sequence is by DNA polymerase and ligase IV. Replication of the ends of DNA strands p306 fig16. 18 A. DNA polymerase can only add nucleotides to a 3’ end (since it grows in a 5’ ? 3’ direction) B. For lagging strand, there is no problem since it replaces RNA primer and joins DNA with ligase C. For leading strand, there is a problem, since the 3’ end of the template strand has a RNA primer, which cannot be replaced with DNA nucleotides (by DNA polymerase) since there is no 3’ end to start from (DNA polymerase cannot just add nucleotides opposite of the DNA template strand – must use a RNA primer) D. This results in successive replicated strands becoming shorter and shorter – the remedy? E. Telomeres – eukaryotic cells have short repetitive nucleotide sequences that do not code for anything 1. elomeres protect the cell from false alarms that there is DNA damage and cause the cell to die since losing these ends don’t mean anything (note that prokaryotes do not have this problem since their DNA is circular with no â€Å"end†) 2. but when telomeres are lost, are they replaced? Yes by telomerase – enzyme that works in conjuncti on with DNA polymerase to add length to telomeres a. p306 fig16. 19 have shortened â€Å"just made† DNA strand b. telomerase is associated with an RNA strand and DNA polymerase c. telomerase lines up the RNA strand with the 3’ DNA strand to serve as a template to have the 3’ end grow d. hen the RNA strand serves as a primer for new growth onto the 5’ strand, then the primer is removed e. result is an elongated DNA strand that was shorted during replication *telomerase is not present in most cells of multicellular organisms (like us) *DNA of older individuals tends to be shorter *telomerase is abundant in germ line cells – those that give rise to gametes *researchers find telomerase in cancer cells – makes sense since these cells replicate often and would have very short DNA (possible cancer therapy is to target their telomerase) How to cite The Molecular Basis of Inheritance, Papers

Mimosa Tenuiflora free essay sample

Mimosa Tenuiflora Mimosa Tenuiflora, or Mimosa Hostilis, is the scientific name of a plant more commonly known as the Mimosa tree or shrub. The mimosa plant is a fern like perennial that can grow up to eight meters tall given optimal growth conditions. The mimosa leaves are attached with a petiolate and arranged alternately and bipinnately lobed with fifteen to thirty three odd bipinnately compounded leaflets. The leaflets themselves are attached in a sessile fashion and have a parallel venation which resembles the opposite arrangement of the leaflets on the leaf. The plane (side view) and entire (above view) margined leaflets have an oblong shape with a mucronate apex, a slightly oblique base, and a glabrous leaflet surface. The stem of the mimosa plant has a modification that results in a food storing and ground anchoring bulb. This bulb tends to form approximately halfway between the surface of the ground and the end of the mimosas long thin taproot. Mimosa Tenuiflora is a member of the Leguminosae family, which is more commonly known as the pea, bean, or legume family. The resemblance to the Leguminosae family can be seen in he presence of root nodules called rhizobia that assist with nitrogen fixation of the plant. Much like common pea plants, Mimosa Tenuiflora produces lightly fleshy pod like fruit that dry and drop to the ground for reproduction. Unlike the pea plant, the mimosa plants fruit has a papery consistency and harbors six to eight hard, flat, light brown seeds that are usually three to four millimeters in length and are dispersed for reproduction through wind and rain. Mimosa Tenuiflora is a tropical plant native to Brazil, but is also found wild in Southern Mexico, Colombia, Nicaragua, El Salvador, Panama, Honduras, and Guatemala. Although native to equatorial parts of South America, Mimosa Tenuiflora is also cultivated as a tree or shrub in many southern areas of the United States. The mimosa plant is rated for a USDA zone nine or higher, which is twenty five degrees Fahrenheit and up, for optimal growth. Being a tropical plant, Mimosa Tenuiflora requires full sun and grows best in sandy well drained soil below five hundred meters in altitude. Mimosa Tenuiflora is a hardy plant though and with its quickly growing taproot and bulb, it can easily split concrete or stone if rooted in a one to two illimeter wide crack. While it is an unassuming looking plant, the mimosa tree has some surprising medicinal uses which range from treating skin lesions for humans and animals, tooth pain, cough, bronchitis, and even a condition called venous ulceration. The ancient Mayans often used roasted mimosa tree bark to treat cuts and lesions, as well as a mimosa bark syrup concoction to treat respiratory problems. In a more recent example, a recent study found that compounds of Mimosa Tenuiflora are helpful in treating venous ulceration; a condition in which improper circulation causes ulcer ike sores on the body. Mimosa Tenuiflora also has the highest content of DMT, a strong naturally occurring psychedelic tryptamine, of any plant in the world; having a content of approximately one percent DMT found in the root bark. Due to this feature, many South American tribes have been known to make a tea from the root bark called Jurema which nas been used in hallucinogenic shamanic rituals tor thousands of years. All of the medicinal properties of the mimosa tree are found within its bark. While not medicinal, the leaves and pods of the plant are high in fiber and protein and can e used as food for animals or even potentially humans in dire need of sustenance. The bark on the stem and the bark on the roots have different medicinal uses and properties. The stem bark of Mimosa Tenuiflora has a variety of medicinal uses that are still being discovered. Native South Americans have used the stem bark of mimosas to treat inflammation, infection, burns, and even respiratory problems. Having very high levels of tannins, mimosa stem bark is an excellent astringent, coagulant, and anti-inflammatory. When applied to serious burns, mimosa stem bark as been found to reduce scar tissue formation and increase skin cell growth. Mimosa Tenuiflora stem bark is also found in many topical wellness products like soap, shampoo, and even skin treatments for herpes, acne, and eczema. In many South American cultures a tea made from the stem bark is used as a cleansing agent for the body for many addictive substances. The bark of the root of the mimosa tree has less effective properties similar to the bark of the stem; however the potency of DMT in the root bark allows some trained individuals to use the plant for spiritual healing and exploration. Some shamans and medicine men in tribal societies make a tea called Jurema from the root bark of mimosa trees and use them during spiritual rituals to try to expand their minds and find supernatural explanations to situations. Many of these medicine men train for years to know how to control the powerful effects of the Jurema and understand the hallucinations and intense emotional experiences caused by the DMT. Some tribes that practice the Jurema ritual also use a complementary tea made from the seeds of P. Harmala, or Syrian Rue, which amplifies the effects of the Jurema; this mixture is called Ayahuasca. Many people ho consume the Jurema or Ayahuasca teas, whether trained or not, claim to have life changing experiences usually associated with hallucinations of god-like or otherworldly beings that expose some revelatory information to the user. Some who experience this find it to be a frighteningly overwhelming experience, while others seem to benefit more psychologically from the feelings. Mimosa tree bark harvested from the stem of the plant has many aforementioned uses, a few of which involve the astringent, coagulant, and anti-inflammatory properties of the bark. Most of the times when these uses are desired out of the ark, it is roasted and ground into a powder for easy direct topical application or to be made into a salve for the same purpose. Mimosa stem powder or cream, usually called tepezchuite, is a good remedy for minor or severe cuts and burns, and is widely effective on many inflammation and bacteria related skin problems. There is direct evidence for the compounds in mimosa stem bark having the ability to generate and sustain collagen, which is why the use of tepezchuite produces less scar tissue and heals wounds so quickly. Teas of the Mimosa Tenuiflora stem bark are made by boiling the bark in water. Due to its astringent compounds, Mimosa tea is somewhat effective in treating mild tooth aches and also good for expelling toxins from the human body during withdraw or detoxification from an addictive substance. A decoction, or water extraction, is made by pounding or grinding the bark in cold water to leech the desired compounds trom the bark. Mimosa decoctions nave been used since Mayan times to treat coughs and bronchitis. Once again the astringent properties of the mimosa bark act as an expectorant to help those with mucus in their throats dislodge it and cough it up. The decoction method is the same method sed by shaman and medicine men to convert the root bark of Mimosa Tenuiflora into Jurema or Ayahuasca. This use of the mimosa tree may lead to new research in the field of Monoamine Oxidase Inhibitors (MAOs) due to the puzzling nature of the bioactivity of the DMT while used for hallucinogenic. Normally, DMT is not orally active to humans because of the presence of the Monoamine Oxidase (MAOs) compounds found in the human body which break down the DMT. However, when Jurema or Ayahuasca is consumed, the DMT is rendered orally active most likely due to a large amount of an unknown, and seemingly very effective, MAO. Mimosa Tenuiflora contains high levels of many medicinal compounds, of which are tannins, saponins, alkaloids, glucosides, luperol, and methoxychalchones. Tannins are responsible for the astringent properties of the mimosa tree, having strong antibacterial, viral, and parasitic properties, as well as the anti-inflammatory and antiulcer properties. Saponins, the compounds responsible for the cleansing effect of mimosa tea, promote the hydrolysis of toxins from the cells of the digestive tract. Alkaloids are common nitrogen based molecules that have a wide range of edical applications including helping with many cardiovascular problems as well as some respiratory problems. Alkaloids are the compounds responsible for the expectorant properties as well as the psychoactive properties being that DMT is an alkaloid. The glucosides in Mimosa Tenuiflora act as a mild purgative which aid in the cleansing properties of mimosa bark. Luperol is a well-known anti-inflammatory compound that has been used to reduce swelling in the paws of rats and is seen to work better than the accepted standard anti-inflammatory. Luperol is clearly esponsible for the anti-inflammatory properties of mimosa tree bark but is also an effective inhibitor of prostate and skin cancers. Similar to Luperol, methoxychalchones are the compounds also responsible for some anti-inflammatory effects as well as some anti-bacterial effects of mimosa bark. Mimosa Tenuiflora stem bark can be used liberally with few health issues. Any topical application of powdered mimosa bark or mimosa salve is overall safe; with perhaps only slight discomfort if applied to sensitive tissues. Mimosa tea and mimosa decoction are also mostly safe with the only risk of health issues being upset tomach or indigestion caused by the astringent properties of the plant when over consumed.

A Midsummer Nights Dream Essays (972 words) - Hermia,

A Midsummer Nights Dream The Realm of Imagination In A Midsummer Night's Dream, Shakespeare uses the green world and its inhabitants as a symbol of imagination. The characters flee from reality to escape the laws that govern everyday life in Athens. The importance of imagination reveals itself when the constraints of everyday life are lost in this realm. The fact that actors fall asleep multiple times reinforces Shakespeare's allusion to an escape from reality. Fairies playfully create a magical scene creating a suspension of disbelief for the actors as well as the audience. The problems that these characters face are remedied because of the ability of the mind to create this mythical world. Harmony is restored to the characters' lives because of their ability to bring fantasy into reality. Shakespeare portrays the power of the imagination as humanity's most divine quality because it allows one to embrace a realm outside of this world and allows one envision fantasy. In Athens, laws of the society threaten the characters' freedom. The ?sharp Athenian law? pursues these characters and causes them to escape into the forest. Lysander states, ?From Athens her house remote seven leagues;/ And she respects me as her only son. /There, gentle Hermia, may I marry thee, /And to that place the sharp Athenian law/ Cannot pursue us?. (I.i.156) Here, Lysander suggests to Hermia that the two of them retreat from society to escape from the law that binds them. Shakespeare uses the forest to represent the human imagination, which is manifested in the ability to dream. He focuses upon the abilities of the human mind to temporarily escape the harsh rules of society. The rules of society do not govern their actions as long as they are in the forest. Helena and Demetrius retreat into the woods, yet these characters are not led into the realm of imagination to escape the persecution of society. Unlike Hermia and Lysander, Demetrius and Helena retreat into the forest because of their infatuation with others. Helena is infatuated with Demetrius, who is infatuated with Hermia. Helena lures Demetrius into the forest by telling him about Hermia and Lysander's plans. Helena states, ?I will go tell him of Hermia's flight. /Then to the wood will he tomorrow night /Pursue her(I.i 246) Both characters flee into imagination because their love is not returned to themselves. They flee into the forest into the realm of chaos and dreams where everything is possible. The elements created within the forest bring the characters into harmony with each other. The fairies rule in the realm of imagination. They are mythical, elusive figures of the forest, responsible for creating illusion and fooling the humans. Oberon, the king of the fairies, is referred to as the ?king of shadows?. This reference shows the elusive nature of the fairies, and their being. They are only a ?shadow? of reality again the forest and fairies are seen elements of imagination. Puck is a character referred to as a ?hobgoblin? responsible for fooling humans to jest for Oberon. These characters enjoy the trickery done unto the humans, which can be used as a metaphor for imagination. One's imagination is sometimes responsible for fooling one's self. The fairies are used to represent this aspect of imagination. A fellow fairy recognizes Puck and describes him as ?he /That frights maidens of the villagery, and sometimes labor in the quern, /And bootless make the breathless huswife churn, /And sometimes make the drink to bear no barm, /Mislead night wanderers, laughing a t their harm.?(II.i.32) Puck is responsible for misleading humans and plays on their minds. The actions Puck is conducting are referred to as ?figments of imagination? for which the fairies are said to be responsible. The fairies here bring magic to the humans in the forest when lovers become crossed in their paths. In the minds of the characters, the fairies in all of these cases have brought life to what is fantasy. The fairies, like dreams, have been able to create an alternate harmonious state for the characters by bringing life to the ordinary and mundane. Though fairies exist in a world within the forest while the humans live in Athens on the outside of imagination, the lines between reality and imagination

Marcia J. Citron essays

Marcia J. Citron essays The works of a composer are not the only factor used to determine canonization; culture and gender play a large part in this process. Citron shows how the Western art canon is the result of a complex mixture of opinions, traditions, and interests that often go unacknowledged and unchallenged. The term canon was applied to music in last twenty years, defined as a specified group or body of related works. 1 It is debatable as to whether works are incorporated into the canon as a pre-existent concept or if the canon is only significant through the application of these works into a articulate and expressed repertoire. The canon is restricting in that it set the criterion for works that are to be included or discounted as marked repertoire. There is a categorization process that takes place in the development of the canon. This process places works into an appropriate group and eliminates those that do not fit the mould of what has been deemed culturally acceptable. Much new music is not accepted into reportorial canons, because the canons of the past have set high standards that do not allow for the conception and recognition of new music. These standards of repertoire are defined by cultural groups that are considered dominant on the basis of class, race, gender, age, oc cupation, nationality, and religious orientation. However, the canon is restricted, because the ideals set by one particular social group may not be appropriate for another; therefore, it is not representative of the whole, rather it merely represents the opinion of an individual group. These individuals often change, presenting a change in the standards of the canon as well as a transformation of the value of the canon as a whole. Textbooks and academic curriculum also influence the construction of the canon. Textbooks emphasize specific works and composers on which instructors and students rely on as a source of musical inform...

Persuade the reader to purchase a hybrid vehicle Essay

Persuade the reader to purchase a hybrid vehicle - Essay Example This model car was developed after realising that traditional automobiles were significantly contributing to greenhouse gas emissions that contribute to the destruction of the environment through global warming. Apart from using natural gas, hybrid cars also use a lithium-ion battery which can be recharged at special recharge points. These cars are environmental friendly since they do not emit any carbon footprint that can damage the environment. Hybrid cars are also fast and efficient which make them ideal for personal and family use. These cars can also be classified as luxury brands and they are very attractive. Toyota and Honda are currently the major actors in this sector and they manufacture economic hybrid cars. The other advantage of buying a hybrid car is that they are easy to maintain in the long run. We are currently living in a world that is characterised by a volatile economy. For instance, the prices of gas and oil are constantly increasing and these have spiral effects on the motorists who have to fork out more money for their daily fuel requirements. Though hybrid cars are expensive to purchase for the first time, it can be seen that they are economic in the long run. Since these are powered by natural gas, it can be observed that there would be no hassle for the motorists to worry about rising prices of oil. The other important point to consider about hybrid cars is that they are all weather terrain vehicles. They can be operated efficiently in any type of environment. Basically, hybrid cars present quite a lot of benefits to the consumers compared to other traditional vehicles though their price may be a setback to the majority of customers. Hybrid cars are environmental friendly and they can provide a long lasting solution to the problem of global warming. Hybrid cars are economic in the long run since they are not powered by fossil fuels that are

Questioner Essay Example | Topics and Well Written Essays - 250 words

Questioner - Essay Example 3. I am a relentless person, I do not believe in giving up. Interior decoration is my passion, albeit discovered late in life. If I don’t get into the program, I will look for ways to express and expand on my interest, probably start a dà ©cor blog, and share and discuss ideas with other people. 4. My calling for interior decoration came after I had already gotten a professional MIS degree. Although I have always had a very attuned aesthetic sense, it was not until I found work with a furniture and interiors company, assisting with chalking up layouts and designs that I really began to enjoy my work. I enjoyed dealing with different spaces and working with clients and their respective lifestyles. Details fascinate me. How a single streak of colour can change the way an entire space feels, is an amazing experience, and a very gratifying feeling. I admit, working professionally as an interior decorator will require a lot of hard work and persistence, however, I feel that I already live, eat & breathe design. As Confucius said, â€Å"Choose a job you love and you will never have to work a day in your